Location(s):
UT Le Bonheur Pediatric Specialists
Outpatient Center
51 N. Dunlap St., Suite 400
Memphis, TN 38105

John DeVincenzo

Medical Director of Molecular Diagnostics and Virology Lab, Le Bonheur Children's Hospital

Professor of Pediatrics, Professor of Molecular Sciences, Microbiology, Immunology, and Biochemistry
Instructor, Biostatistics and Preventive Medicine, The University of Tennessee Health Science Center

Phone Number: 1-866-870-5570
Board Certification:

American Board of Pediatrics, Sub-board Infectious Disease

Medical School:

Vanderbilt University

Internship:

Center for Health Sciences, University of California at Los Angeles - Pediatrics

Residency:

Center for Health Sciences, University of California at Los Angeles - Pediatrics

Fellowship:

Children's Hospital Medical Center and Harvard University - Clinical Infectious Diseases

Awards and Honors:

Recognized in US News & World Report Top Doctors, Recognized in Best Doctors in America

Healthcare Heroes Award for Innovation, Memphis Business Journal (2008)

Best Advance in Therapy and Prevention of a Microbial Disease (ICAAC 2007)

Specialties:

DeVincenzo's research has focused on understanding the pathogenesis of Respiratory Syncytial Virus (RSV) in children and using this understanding to develop therapeutic and prevention strategies against this virus. He is the author of over 150 original published abstracts and papers on this subject. His research focus has shifted to apply knowledge of RSV dynamics to the development of novel therapeutics for RSV, specifically the development of RNA interference-based therapeutics for RSV. For his groundbreaking proof-of-concept work applying RNA interference concepts to develop human therapeutics, DeVincenzo’s study was listed as one of the most influential papers in medicine in 2010 by the American Society for Microbiology.

Selected publications
1. DeVincenzo JP, Hall CB, Kimberlin DW, Sanchez PJ, Rodriguez WJ, Jantausch BA, Corey L, Khan JS, Englund JA, Suzich JA, Palmer-Hill FJ, Branco L, Johnson S, Patel NK, Piazza FM. Surveillance of clinical respiratory syncytial virus (RSV) isolates for palivizumab (Synagis®) resistant mutants. J. Infect. Dis. 2004; 190(5): 975-978.

2. DeVincenzo JP, El Saleeby CM, Bush AJ. Respiratory syncytial virus load predicts disease severity in previously healthy infants. J. Infect. Dis. 2005; 191(11): 1861-1868.

3. Avadhanula V, Rodriguez CA, DeVincenzo JP, Webby RJ, Ulett GC, Adderson EE. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species and cell type-dependent manner. J. Virol 2006; 80(4): 1629-1636. PMC ID: PMC1367158

4. El Saleeby CM, Somes GW, DeVincenzo JP, Gaur A. Risk factors for severe RSV disease in children with cancer: the importance of lymphopenia and young age. Pediatrics 2008; 121(2): 235-243.

5. DeVincenzo JP, Cehelsky JE, Alvarez R, Elbashir S, Harborth J, Toudjarska I, Nechev L, Murugaiah M, Van Vliet A, Vaishnaw AK, Meyers R. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic against RSV. Antiviral Res. 2008; 77(3): 225-231.

6. Miyairi I, DeVincenzo JP. Human genetic factors and RSV disease severity. Clin. Microbiol. Rev. 2008; 21(4): 686-703. PMC ID: PMC2570150

7. Alvarez R, Elbashir S, Borland T, Toudjarska I, Hadwiger P, John M, Roehl I, Morskyaya SS, Martinello R, Kahn J, Van Ranst M, Tripp RA, DeVincenzo JP, Pandey R, Maier M, Nechiv L, Manoharan M, Koteliansky V, Meyers R. RNA interference-mediated silencing of the RSV nucleocapsid defines a potent anti-viral strategy. Antimicrobial Agents Chemother. 2009; 53(9): 3952-3962. PMC ID: PMC2737834

8. DeVincenzo JP. Harnessing RNA interference to develop neonatal therapies: From Nobel Prize winning discovery to proof of concept clinical trials. Early Human Dev. 2009; 85(10): S31-S35.

9. DeVincenzo JP, Wilkinson T, Vaishnaw A, Cehelsky J, Meyers R, Nochur S, Harrison L, Meeking P, Mann A, Moane E, Oxford J, Pareek R, Moore R, Walsh E, Studholme R, Dorset P, Alvarez R, Lambkin-Williams R. Viral load drives disease in humans experimentally infected with wild-type respiratory syncytial virus. Am. J. Resp. Crit. Care Med. 2010; 182: 1305-1314. PMC ID: PMC3001267

10. DeVincenzo JP, Lambkin-Williams R, Wilkinson T, Cehelsky JE, Nochur S, Walsh E, Meyers R, Gollob J, Vaishnaw AK. A randomized, double-blind, placebo-controlled study of an RNA interference (RNAi)-based therapy directed against RSV. Proc Natl Acad Sci U S A, 2010; 107: 8800-8805. PMC ID: PMC2889365

11. Zamora, MR, Budev M, Rolfe M, Gottlieb J, Humar A, Devincenzo J, Vaishnaw A, Cehelsky J, Albert G, Nochur S, Gollob JA, Glanville, AR. RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. Am J Respir Crit Care Med. 2011 Feb 15;183(4):531-8. Epub 2010 Sep 17.

12. El Saleeby C, Bush AJ, Harrison LM, Aitken JA, DeVincenzo JP. Respiratory syncytial virus load, viral dynamics and disease severity in previously healthy naturally infected children. J Infect Dis, 2011 Oct;204(7):996-1002. PMC ID: PMC3203391

13. Malboeuf C, Yang X, Charlebois P, Qu J, Berlin A, Casali M, Pesko K, Boutwell C, DeVincenzo J, Ebel G, Allen T, Zody M, Henn M, Levin JZ. Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification. Nucleic Acids Res. 2013 Jan 7;41(1):e13. Epub 2012 Sep 8. PMC ID: PMC3592391

14. Bagga B, Woods CW, Veldman TH, Gilbert A, Mann A, Balaratnam G, Lambkin-Williams R, Oxford JS, McClain MT, Wilkinson T, Nicholson BP, Ginsburg GS, DeVincenzo JP. Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals. Antivir Ther, 2013 May 28. doi:10.3851/IMP2629. [Epub ahead of print]

15. Hertz T, Oshansky CM, Roddam PL, DeVincenzo JP, Caniza MA, Jojic N, Mallal S, Phillips E, James I, Halloran ME, Thomas PG, and Corey L. HLA targeting efficiency correlates with human t-cell response magnitude and with mortality from influenza a infection. Accepted to Proc Natl Acad Sci U S A, 6/18/2013. PMC Journal - In Process