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David Hains, MD

Specialties:  Nephrology

Associate Professor, University of Tennessee Health Science Center

Program Director, Nephrology Fellowship Program, Le Bonheur Children's Hospital

Director, Innate Immunity Translational Research Center, Le Bonheur Children's Hospital

Patient Care Emphasis:

Grant funding:

8/2015-7/2019 1R01DK106286-01.  “The interface between critical acid-base mediators and the renal bacterial defense.”  Co-PI:  Hains.


David Hains, MD

Specialties:  Nephrology

Associate Professor, University of Tennessee Health Science Center

Program Director, Nephrology Fellowship Program, Le Bonheur Children's Hospital

Director, Innate Immunity Translational Research Center, Le Bonheur Children's Hospital

UT Le Bonheur Pediatric Specialists
Le Bonheur Outpatient Center - Main Campus
51 N. Dunlap St., 4th Floor
Memphis, TN 38105
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Medical School

Indiana University School of Medicine

Board Certification

American Board of Pediatrics, Certified in Pediatrics
American Board of Pediatrics, Certified in Pediatric Nephrology


Nationwide Children's Hospital/Ohio State University School of Medicine

Awards and Honors

2004 Lyman T. Meiks Research Award for Pediatrics, Indiana
University School of Medicine. Indianapolis, IN.
2006 American Society of Nephrology Resident Travel Grant. Philadelphia, PA.
2006 American Society of Pediatric Nephrology Trainee Research Award.
2006 Certificate of Research Distinction. Columbus Children’s Hospital.
2007 Ohio State University Medical Center Research Day Poster Travel Grant Award.
2007 Society of Pediatric Research House Officer Research Award
2007 AAP Travel Grant
2007 Code Busters Award-Outstanding Senior Resident Award. Columbus Children’s Hospital.
2007 NIH Loan Repayment Award.
2008 Pediatric Academic Society Travel Grant2009 Top Basic Science Presentation. Midwest Nephrology
Fellows Research Day.
2009 Outstanding Housestaff Publication Award. Nationwide
Children’s Hospital.
2011 John E. Lewy Foundation Advocacy Scholars Program,
American Society of Pediatric Nephrology
2012 NIH Loan Repayment Award
2013 NIH Loan Repayment Award

Selected Research

1. Eugster E, Hains D, DiMeglio L. Initial Management of Infants with Intersex Conditions in a Tertiary Care Setting: A Cautionary Tale. Journal of Pediatric Endocrinology & Metabolism. 2006 Feb; 19(2): 191-2.

2. Poladia DP, Kish K, Kutay B, Hains D, Kegg H, Zhao H, and Bates CM. Role of fibroblast growth factors 1 and 2 in the metanephric mesenchyme. Developmental Biology. 2006 Mar 15; 291(2): 325-39.

3. Hains D, Sims-Lucas S, Kish K, Saha M, McHugh K, Bates CM. Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatric Research. 2008 Dec; 64(6):592-8.

4. Hains D, Bates, CM, Ingraham S, Schwaderer AL. Management and Etiology of the Unilateral Multicystic Dysplastic Kidney: A Review. Pediatric Nephrology. 2009 Feb; 24(2):233-41. Epub 2008 May 15.

5. Sims-Lucas S, Cullen-McEwen L, Eswarakumar VP, Hains D, Kish K, Becknell B, Zhang J, Bertram JF, Wang F, Bates CM. Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. American Journal of Physiology, Renal Physiology. 2009 Nov;297(5):F1208-19. Epub 2009 Sep 9. PMID: 19741018.

6. Hains DS, Sims-Lucas S, Carpenter A, Saha M, Murawski I, Kish K, Gupta I, McHugh K, Bates CM. High Incidence of Vesicoureteral Reflux in Mice With Fgfr2 Deletion in Kidney Mesenchyma. Journal of Urology. 2010 May;183(5):2077-84. Epub 2010 Mar 19. PMID: 20303521.

7. Ingraham S, Saha M, Carpenter A, Robinson M, Ismail I, Robinson M, Hirselj D, Koff S, Hains D, Bates C, McHugh K. “Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy.” Pediatric Research. 2010 Aug 24. PMID: 20736884.

8. Spencer JD, Schwaderer A, McHugh K, Hains DS. Pediatric urinary tract infections: An analysis of hospitalizations, charges, and costs in the USA. Pediatric Nephrology. 2010 Aug 14. PMID: 20711740.

9. Becknell B, Zender G, Houston R, Baker P, McBride KL, Hains D, Dorin-Bogdan Borza D, Schwaderer AL. Novel X-linked glomerulopathy associated with a COL4A5 missense mutation in a noncollagenous interruption. Kidney International. 2011 Jan;79(1):120-7. Epub 2010 Sep 29.

10. Spencer JD, Bates CM, Mahan JD, Niland ML, Staker SR, Hains DS, Schwaderer AL. The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection. Journal of Pediatric Urology. 2010 Dec 1. PMID: 21126919.

11. Hains DS, Reagan P, Smoyer WE. Do Declining Private Insurance Coverage Rates Influence Pediatric Hospital Charging Practices? Clinical Pediatrics (Phila). 2011 May;50(5):417-23. Epub 2011 Feb 27.

12. Spencer JD, Schwaderer A, DiRosario J, McHugh K, McGillivary G, Justice S, Carpenter A, Baker P, Harder J, and Hains DS. Ribonuclease 7: a potent antimicrobial peptide within the human urinary tract. Kidney International. 2011 Jul;80(2):174-80. PMID: 21525852.

13. Spencer JD, Schwaderer A, McHugh K, Vanderbrink B, Becknell B, Hains DS. The demographics and costs of inpatient vesicoureteral reflux management in the USA. Pediatric Nephrology. 2011 May 10. PMID: 21556713.

14. Becknell B, Pais P, Onimoe G, Rangarajan H, Schwaderer AL, McHugh KM, Ranalli MA, Hains DS. Hepatoblastoma and Prune belly syndrome: A Potential Assocation. Pediatric Nephrology. 2011 May 20. [Epub ahead of print] PMID: 21597971.

15. Schwaderer AL, Srivastava T, Schueller L, Cronin R, Mahan JD, Hains D. "Dietary modifications alone do not improve bone mineral density in children with idiopathic hypercalciuria". Clinical Nephrology. 2011 Nov;76(5):341-7. PMID: 22000552.

16. Maguire MA, Franz T, Hains DS. "A Clinically Significant Interaction between Tacrolimus and Multiple Proton Pump Inhibitors in a Kidney Transplant Recipient". Pediatric Transplantation. 2011 Aug 23. PMID: 21883747.

17. Becknell B, Hains DS, Schwaderer AL, Vanderbrink BA, Spencer JD, Reagan PB, McHugh KM. “Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy.” Journal of Pediatric Urology. 2012 Oct;8(5):470-6.2011. Nov 23. [Epub ahead of print]

18. Ayoob R, Hains DS, Smoyer WE. "Trends in Hospitalization Characteristics for Pediatric Nephrotic Syndrome in the USA.” Clinical Nephrology. 2012: Vol 78 (2).

19. Cha S, Patel HP, Hains DS, Mahan JD. “The Effects of Hypertension on Cognitive Function in Children and Adolescents.” International Journal of Pediatrics. 2012: 891094. Epub 2012 Feb 28.

20. Carpenter A, Paulus A, Robinson M, Bates CM, Robinson ML, Hains D, Kline D, McHugh KM. “3-Dimensional Morphometric Analysis of Murine Bladder

Development and Dysmorphogenesis.” Developmental Dynamics. 2012 Mar;241(3):522-33. doi: 10.1002/dvdy.23744. Epub 2012 Jan 31. PMID: 22275180.

21. Spencer JD*, Hains DS (co-first author)*, Porter E, Bevins CL, DiRosario J, Becknell B, Wang H, and Schwaderer AL*. “Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract”. PLoS ONE. 2012;7(2):e31712. Epub 2012 Feb 16. PMID: 22359618.

22. Wang H, Schwaderer AL, Bartz JD, Kline J, Spencer JD and Hains DS. “Contribution of Structural Domains to Ribonuclease 7's Activity Against Uropathogenic Bacteria.” Antimicrob Agents Chemother. 2013 Feb;57(2):766-74. PMID: 23183439.

23. Spencer JD, Schwaderer AL, Wang H, Bartz JD, Kline J, McHugh K, Baker P and Hains DS. “Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.” Kidney Int. 2013 Apr;83(4):615-25. doi: 10.1038/ki.2012.410. Epub 2013 Jan 9. PMID: 23302724.

24. Janjua HS, Hains DS, Mahan JD. “Renal Transplantation in United States: Economic Burden and Recent Trends Analysis.” Progress in Transplantation. 2013 Mar;23(1):78-83. PubMed PMID: 23448826.

25. Gbadegesin RA, Brophy PD, Adeyemo A, Hall G, Gupta IR, Hains D, Bartkowiak B, Rabinovich CE, Chandrasekharappa S, Homstad A, Westreich W, Wu G, Yutao Liu, Holanda D, Clarke J, Lavin P, Selim A, Miller S, Wiener JS, Ross SS, Foreman J, Rotimi C, Winn MP. “TNXB Mutations Can Cause Vesicoureteral Reflux.” J Am Soc Nephrol. 2013 Apr 25. [Epub ahead of print] PMID: 23620400.

26. Becknell MB, Carpenter A, Bolon B, Asplin JR, Ingraham SE, Hains DS, Schwaderer AL, McHugh KM. “Struvite Urolithiasis and Chronic Urinary Tract Infection in a Murine Model of Urinary Diversion.” Urology. 2013 Mar 20. PubMed PMID: 23523293.

27. Spencer JD, Watson J, Becknell MB, Schwaderer AS, Hains DS. “The Innate Immune Response During Urinary Tract Infection and Pyelonephritis.” Pediatr Nephrol. 2013 Jun 5. [Epub ahead of print] PubMed PMID: 23732397.

29. Becknell B, Carpenter A, Allen JL, Wilhide ME, Ingraham SE, Hains DS, McHugh KM. (2013) Molecular Basis of Renal Adaptation in a Murine Model of Congenital Obstructive Nephropathy. PLoS One. 2013 Sep 4;8(9):e72762. doi: 10.1371/journal.pone.0072762. PMID: 24023768

30. Rheault M, Wei C, Hains DS, Wang W, Kerlin BA, Smoyer BS. Increasing Frequency of Acute Kidney Injury Amongst Children Hospitalized with Nephrotic Syndrome. Pediatr Nephrol. 2013 Sep 14. [Epub ahead of print] PMID: 24037143

31. Spencer JD, Schwaderer AL, Eichler T, Wang H, Kline J, Justice SS, Cohen DM, Hains DS. "Endogenous Ribonuclease Inhibitor Regulates the Antimicrobial Activity of Ribonuclease 7 in the Human Urinary Tract." Kidney Int. 2013 Oct 9. doi: 10.1038/ki.2013.395. [Epub ahead of print] PMID: 24107847

32. Becknell B, Spencer JD, Carpenter A, Chen X, Singh A, Ploeger S, Kline J, Ellsworth P, Li B, Proksch E, Schwaderer A, Hains DS, Justice SS, McHugh KM. “Expression and Antimicrobial Function of Beta-Defensin 1 in the Lower Urinary Tract.” PLoS One. 2013 Oct 21;8(10):e77714. doi: 10.1371/journal.pone.0077714. PMID: 24204930

33. Skandarajah A (student), Hains DS and Schwaderer AL. “UTI, Familial Occurrence and Association with other infections.” Journal of Clinical Pediatric Nephrology. 2014 Vol 2: 1.

34. Shin HS (resident), Becknell B, Reagan P, Mahan JD, Hains DS. “Modern U.S.A. Trends in Demographics, Extrarenal Manifestations, and Inpatient Healthcare Utilization for Hemolytic Uremic Syndrome.” Accepted to Journal of Clinical Pediatric Nephrology on April 2, 2014.

35. Becknell B, Eichler T, Beceiro S, Li B, Easterling R, Carpenter AR, Partida-Sanchez S, Hains DS, Spencer JD. “Ribonuclease 6 and Ribonuclease 7 Expression and Antimicrobial Function in the Human and Murine Urinary Tract.” Accepted to Kidney International on June 11, 2014.