Featured Researchers

Published On 04/01/2014

Young In Kim Hoehamer, PhD

Instructor
Division of Infectious Diseases
The University of Tennessee Health Science Center
Le Bonheur Children’s Hospital
Children’s Foundation Research Institute

Education:

Undergraduate – Kangwon National University
Graduate – Kangwon National University (MS), Seoul National University (PhD)
Post-Graduate – Seoul National University, The University of Tennessee Health Science Center

Area of Interests: Using cellular biology and immunology to investigate RSV infection in children and adults.

Grant funding:

  • Study on molecular mechanisms of IRAK-M expression by TLR ligands (Le Bonheur Children’s Hospital)
  • PKD1 in the pathogenesis of hypersensitivity pneumonitis (Le Bonheur Children’s Hospital)
  • Development of Mathematical Models to Capture the Viral Kinetics of Respiratory Syncytial Virus Infections In vitro and In vivo (AstraZeneca)

Published research

  • Hur DY, Kim DJ, Kim S, Kim YI, Cho D, Lee DS, Hwang Y, Bae K, Chang KY, Lee WJ. Role of follicular dendritic cells in the apoptosis of germinal center B cells. Immunol Lett. 2000 May 1;72(2):107-11.
  • Hur DY, Kim S, Kim YI, Min HY, Kim DJ, Lee DS, Cho D, Hwang YI, Hwang DH, Park SH, Ahn HK, Chang KY, Kim YB, Lee WJ. CM1, a possible novel activation molecule on human lymphocytes. Immunol Lett. 2000 Oct 3;74(2):95-102.
  • Park H, Byun D, Kim TS, Kim YI, Kang JS, Hahm ES, Kim SH, Lee WJ, Song HK, Yoon DY, Kang CJ, Lee C, Houh D, Kim H, Cho B, Kim Y, Yang YH, Min KH, Cho DH. Enhanced IL---18 expression in common skin tumors. Immunol Lett. 2001 Dec 3;79(3):215-9.
  • Kim D, Hur DY, Kim YS, Lee K, Lee Y, Cho D, Kang JS, Kim YI, Hahm E, Yang Y, Yoon S, Kim S, Lee WB, Park HY, Kim YB, Hwang YI, Chang KY, Lee WJ. CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria controlled manner in Raji cells. Hum Immunol. 2002 Jul;63(7):576-87.
  • Cho D, Seung Kang J, Hoon Park J, Kim YI, Hahm E, Lee J, Yang Y, Jeon J, Song H, Park H, KimT, Pang S, Kim CW, Il Hwang Y, Jae Lee W. The enhanced IL--18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT). Biochem Biophys Res Commun. 2002 Oct 25;298(2):289-95.
  • Kim YI, Park S, Jeoung DI, Lee H. Point mutations affecting the oligomeric structure of Nm23 H1 abrogates its inhibitory activity on colonization and invasion of prostate cancer cells. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):281-9.
  • Kang JS, Cho D, Kim YI, Hahm E, Yang Y, Kim D, Hur D, Park H, Bang S, Hwang YI, Lee WJ. Lascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8 independent pathway. Cancer Immunol Immunother. 2003 Nov;52(11):693-8.
  • Cho D, Hahm E, Kang JS, Kim YI, Yang Y, Park JH, Kim D, Kim S, Kim YS, Hur D, Park H, Pang S, Il Hwang Y, Lee WJ. Vitamin C down regulates interleukin---18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signaling in B16F10 murine melanoma cells. Melanoma Res. 2003 Dec;13(6):549-554.
  • Cho D, Kim YI, Kang J, Hahm E, Yang Y, Kim D, Kim S, Kim Y, Hur D, Park HJ, Hwang YI, Kim T, Lee WJ. Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin's lymphoma cells. J. Clinical Immunol. 2004 Sep; 24(5): 552-559.
  • Yang Y, Hahm E, Kim Y, Kang J, Lee W, Han I,Myung P, Kang H, Park H, Cho D. Regulation of IL-8 expression by CRH in mouse microglial cells. Immunol Lett. 2005 May 15;98(2):291-6.
  • Kang JS, Cho DH, Kim YI, Hahm ES, Kim YS, Jin SN, Kim HN, Kim DJ, Hur DY, Park HJ, Hwang YI, Lee WJ. Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down regulation of transferring receptor dependent iron uptake. J Cell Physiol. 2005 Jul;204(1):192-7.
  • Kim YS, Park GB, Choi YM, Kwon OS, Song HK, Kang JS, Kim YI, Lee WJ, Hur DY. Ligation of centrocyte/centroblast marker 1 on Epstein-Barr virus – transformed B lymphocytes induces cell death in a reactive oxygen species-dependent manner. Hum Immunol. 2006 Oct; 67(10):795 807.
  • Hahm E, Jin DH, Kang JS, Kim YI, Hong SW, Lee SK, Kim HN, Jung DJ, Kim JE, Shin DH, Hwang YI, Kim YS, Hur DY, Yang Y, Cho D, Lee MS, Lee WJ. The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. J Cell Biochem. 2007 Nov 1;102(4):1002-10.
  • Kim YI, Park JE, Martine A. Yi AK. CpG DNA prevents liver injury and shock---mediated death by modulating expression of IL-1R – associated kinase family proteins. J. Biol. Chem. 2008 May 30;283(22):15258-70.
  • Talati AJ, Kim HJ,Kim YI, Yi AK, English BK. Role of bacterial DNA in macrophage activation by group B streptococci. Microbes Infect. 2008 August - September;10(10-11):1106-1113.
  • Park JE, Kim YI, Yi AK. Protein Kinase D1: A new component in Toll-Like receptor 9 signaling. Immunol 2008 Aug 1;181(3):2044-55.
  • Park JE, Kim YI, Yi AK. Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. J Immunol. 2009 May15;182(10):6316-27.
  • Kim YI, Park JE, BrandD, Fitzpatrick EA, Yi AK. Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula. J Immunol. 2010 Mar 15;184(6):3145-56.
  • Kim YI, Park JE, Kwon KH, Hong CY, Yi AK. IRAK2- and PKD1-dependent regulation of interleukin-1 receptor-associated kinase-monocyte expression by CpG DNA. PLoS ONE 2012 Aug 7(8):e43970.
  • Ormier S, Shrestha B,Saravia J, Shen L,DeVincenzo J, Kim YI, and You D. Limited Type I IFNs and lasmacytoid DendriticCells during Neonatal Respiratory Syncytial Virus Infection Permit Immunopathogenesis upon Reinfection" J Virology 2014 (revised)
  • Murphy R,Kim YI,Majumdar S, Sullivan A, Harrison L, Aitkin J, DeVincenzo JP. Respiratory Syncytial Virus plaque morphology as it relates to RSV strain, viral load, and disease severity in children. The Journal of Pediatric Infectious Disease Society. (in preparation)
  • Upadhyay K, Park JE, Kim YI, Meals E, Talati A, English BK and Yi AK. Group B streptococci induce proinflammatory responses via a protein kinase D1-dependent pathway (in preparation).