Co-Director, Heart Institute
St. Jude Chair, Pediatric Cardiology
Vice Chair, Strategic Advancement
Le Bonheur Children's Hospital
St. Jude Children's Research Hospital
Chief and Professor, Pediatric Cardiology
The University of Tennessee Health Science Center
Patient Care Emphasis
diagnostic and therapeutic advances for cardiomyopathies (heart muscle disease), heart failure, heart transplantation and cardiovascular genetics
University of Cincinnati College of Medicine (1982)
B.S. in Biology (1974) University of Cincinnati
M.S. in Cell Biology (1977) University of Cincinnati
American Board of Pediatrics
Sub-board of Pediatric Cardiology
Children's Hospital Medical Center (1982-1983)
Children's Hospital Medical Center (1983-1985)
Baylor College of Medicine, Texas Children's Hospital (1985-1989)
1991 Richard D. Rowe Award, The Society for Pediatric Research
1993 Young Investigator Award, American Academy of Pediatrics, Section on Cardiology
1997 Pfizer Visiting Professorship in Cardiovascular Medicine
1998 Distinguished Service Award, American Heart Association
2003 Michael DeBakey Excellence in Research Award
2004 Cincinnati Children’s Hospital Wall of Honor
2007 American College of Cardiology Distinguished Scientist Award (Basic)
2007 American Heart Association T. Duckett Jones Lecturer
2010 Council on Cardiovascular Disease of the Young (CVDY), American Heart Association Meritorious Achievement Award
2012 Simon Dack Award, American College of Cardiology
2013 American Heart Association Basic Research Prize
Fellow, American Heart Association
Fellow, American College of Cardiology
Fellow, American Academy of Pediatrics
Member, Society for Pediatric Research
Member, International Society of Heart and Lung Transplantation
Member, Heart Failure Society of America
Member, International Society for Pediatric Mechanical Cardiopulmonary Support
Member, Heart Rhythm Society
Member, International Society of Cardiomyopathies and Heart Failure
Member, American Association of Physicians
Tsubata S, Bowles KR, Vatta M, Zintz C, Titus J, Muhonen L, Bowles NE, Towbin JA. Characterization of mutations in the human ?-sarcoglycan gene in familial and sporadic dilated cardiomyopathy. J Clin Invest 106:655-662, 2000.
Shirali GS, Ni J, Chinnock RE, Vander Dussen LK, Johnson JK, Bowles NB, Towbin JA. Association of viral genome with transplant coronary arteriopathy and graft loss in children following cardiac transplantation:
Identification using PCR. N Engl J Med 344:1498-1503, 2001.
Towbin, JA, Bowle NE. The failing heart. Nature 415: 227-233, 2002.
Vatta M, Stetson SJ, Perez-Verdia A, Entman ML, Noon GP, Torre-Amione G, Bowles NE, Towbin JA. Molecular remodeling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance device therapy. Lancet 2002 Mar 16;359(9310):936-41.
Bowles NE, Ni J, Kearney DL, Pauschinger M, Schultheiss HP, McCarthy R, Hare J, Bricker JT, Bowles KR, Towbin JA. Detection of viruses in myocardial tissues by polymerase chain reaction. evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol. 42:466-472, 2003.
Towbin JA, Lowe AM, Colan SD, Sleeper LA, Orav EJ, Clunie S, Messere J, Cox GF, Lurie P, Hsu D, Canter C, Wilkinson JD, Lipshultz SE. Incidence, causes and outcomes of dilated cardiomyopathy in children. JAMA, 296:1867-1876, 2006.
Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, Defreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/ cardiomyopathy. Circ Res. 99:646-655, 2006.
Towbin JA. Scarring in the heart: A reversible phenomenon? N. Engl J. Med, 351:1767-1768, 2007.
Qian L, Mohapatra B, Akasaka T, Liu J, Occor K, Towbin JA, Bodmer R. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proc Natl Acad Sci, USA (PNAS) 105:19833-19838, 2008.
Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE. Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med 358: 1899-1908, 2008.
Moulik M, Vatta M, Witt SH, Arola AM, Murphy RT, McKenna WJ, Boriek AM, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA. ANKRD1, the Gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 54:325-333, 2009.
Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet, 375:752-762, 2010.
Xu T, Yang Z, Vatta M, Rampazzo A, Beffagna G, Pillichou K, Scherer SE, Saffitz J, Kravitz J, Zareba W, Danieli GA, Lorenzon A, Nava A, Bauce B, Thiene G, Basso C, Calkins H, Gear K, Marcus F, Towbin JA; Multidisciplinary study of right ventricular dysplasia investigators. Compound and digenic heterozygosity contributes to arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol. 55:587-597, 2010.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA: Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 56:1493-1502, 2010.
Purevjav E, Arimura T, Augustin S, Huby AC, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna WJ, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PM, Weintraub RG, Kitaura Y, Ackerman MJ, Kimura A, Towbin JA. Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet. 21:2039-2053, 2012.
Maiellaro-Rafferty K, Wansapura JP, Mendsaikhan U, Osinska H, James JF, Taylor MD, Robbins J, Kranias EG, Towbin JA, Purevjav E. Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy. J Mol Cell Cardiol. 60C:151-160, 2013.
Burns KM, Byrne BJ, Gelb BD, Kuhn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN. New Mechanistic and Therapeutic Targets for Pediatric Heart Failure: Report from a National Heart, Lung, & Blood Institute Working Group. Circulation 130:79-86, 2014.
Towbin JA, Lorts A, Jefferies JL. Left Ventricular Noncompaction Cardiomyopathy. Lancet 386(9995):813-25 2015.