Genetics Division Chief, Le Bonheur Children's Hospital
Professor, University of Tennessee Health Science Center
Patient Care Emphasis
Genetic syndromes associated with obesity and abnormal body fat distribution (e.g., congenital lipomatoses and lipodystrophies)
Research interests include:
- Mechanisms by which genes regulate body composition
- Genomic factors that contribute to HIV and TB progression in African children
University of Cincinnati College of Medicine
MD, University of Cincinnati College of Medicine
PhD, University of Cincinnati College of Medicine
American Board of Medical Genetics and Genomics
Pediatrics, Baylor College of Medicine
Medical Genetics, Baylor College of Medicine
Member, Society for Pediatric Research
Member, National Institutes of Health study section, CADO
Committee Member, Institute of Medicine, the National Academies of Science, Engineering and Medicine
American Society of Human Genetics
Society for Pediatric Research
National Medical Association
T. Varga R. Mounier, A. Patsalos, P. Gogolák, M. Peloquin, A. Horvath, A. Pap, B. Daniel, G.
Nagy, E. Pintye, S. Póliska, S. Cuvellier, S. Ben Larbi, B.E. Sansbury, M. Spite, C.W. Brown, B.
Chazaud and L. Nagy (2016) PPAR-gamma repair macrophages controls GDF3 and skeletal muscle regeneration after acute injury. Immunity (accepted).
M. Namwanje, C.W. Brown (2016) Activins and Inhibins: Roles in Development, Physiology, and Disease. Cold Spring Harb. Perspect. Biol. 8: PMID: 27328872
S.R. Lalani, J. Zhang, C.P. Schaaf, C.W. Brown*, P. Magoulas, C.-H. Tsai, A. El-Gharbawy, K. J. Wierenga, D. Bartholomew, C.-T. Fong, T. Dieber, M.K. Kukolich, L.C. Burrage, E. Austin, K. Keller, F. Fernandez, T. Lotze, A. Wilfong, G. Purcarin, W. Zhu, W. J. Craigen, M. McGuire, D. M. Muzny, J. R. Lupski, C. M. Eng, R. A. Gibbs, A. L. Beaudet, Y. Yang, M. C. Wang and F. Xia (2014) Mutations in PURA cause profound neonatal hypotonia, seizures and encephalopathy in the 5q31.3 microdeletion syndrome. Am. J. Hum. Genet. 95: 579-583. PMC4225583 (co-first author designation).
Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR (2014). Combinatorial actions of Tgf and Activin ligands romote oligodendrocytedevelopment and CNS myelination. Development 141: 2414-28.
H3Africa consortium, Brown CW* (2014). Enabling the genomic revolution in Africa. Science 344: 1346-8. *co-author
Hanchard N, Murdock D, Magoulas P, Bainbridge M, Muzny D, Wu YQ, Wang M, McGuire A, Lupski J, Gibbs R, Brown CW (2013). Exploring the utility of whole-exome sequencing as a diagnostic tool in a child with atypical episodic muscle weakness. Clin. Genet. 83: 457-61.
Zamani N, Brown CW (2011). Emerging roles for the transforming growth factor- superfamily in regulating adiposity and energy expenditure. Endocr. Rev. 32: 387- 403.
Bournat JC, Brown CW (2010). Mitochondrial dysfunction in obesity. Curr. Opin. Endocrinol. Diabetes Obes. 17: 446-52.
Li L, Shen JJ, Bournat JC, Huang L, Chattopadhyay A, Li Z, Shaw C, Graham BH, Brown CW (2009). Activin signaling: effects
Shen JJ, Huang L, Li L, Jorgez C, Matzuk MM, Brown CW (2009). Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose. Mol. Endocrinol. 23: 113-23.
Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, Kumar TR, Matzuk MM (2007). Intraovarian activins are required for female fertility. Mol. Endocrinol. 21: 2458-71.
Chen C, Ware SM, Sato A, Houston-Hawkins DE, Matzuk MM, Shen MM, Brown CW (2006). The Vg1-related protein GDF3 regulates Nodal expression in the pre-gastrulation mouse embryo. Development 133: 319- 29.
Brown CW, Li L, Houston-Hawkins DE, Matzuk MM (2003). Activins are critical modulators of growth and survival. Mol. Endocrinol. 17: 2404-17.
Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM (2000). Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nature Genet. 25: 453-457.