Le Bonheur and UTHSC Fellow Develops Novel Scoring System for HAEC Diagnosis

MEMPHIS, Tenn. - In the largest study to date reviewing Hirschsprung-associated enterocolitis (HAEC) diagnostic scoring systems, a novel scoring system for HAEC developed by Le Bonheur Children’s Hospital and the University of Tennessee Health Science Center Pediatric Surgery Fellow Ruth A. Lewit, MD, MPH, was recently published in the Journal of Surgical Research. This new scoring system may help reduce the rate of underdiagnosis of HAEC, allowing for earlier diagnosis and treatment of patients. Of the 369 episodes of HAEC reviewed in the study, 173 (46%) met the diagnostic cutoff for the new score but did not meet cutoffs for previous scoring systems used for HAEC.

“Improved diagnosis of HAEC has the potential to reduce hospital admissions, limit morbidity and improve outcomes,” said Lewit. “This novel scoring system for HAEC has several advantages over previous scoring systems, but most importantly may help reduce the rate of underdiagnosis of HAEC.”

Two scoring systems exist for diagnosing HAEC – the Pastor score, published in 2008, and the Frykman score, published in 2018. The accuracy of these scores, however, is limited due to their restrictive nature and neither has been widely adopted in clinical practice. Lewit and her team aimed to develop a new diagnostic tool that provided better utility and diagnostic accuracy in a clinical setting.

For the purpose of this study, an HAEC diagnosis was defined as treatment consisting of antibiotics, bowel rest and rectal irrigations. This study evaluated the existing HAEC systems and developed a new scoring system by evaluating 1,450 encounters with 200 patients and 369 HAEC episodes at four centers worldwide. The Pastor and Frykman scores were retrospectively calculated for each episode, and Lewit identified six variables to include in the new scoring system.

The variables that are significantly associated with diagnosis of HAEC – fever, bloody diarrhea, obstipation, distention, dilated loops of bowel on x-ray and leukocytosis – were used to create a new score. When reviewing HAEC episodes through the Pastor and Frykman scores, 46% did not meet their criteria but did meet the cutoff for the new score. This suggests that 46% of patients would have been underdiagnosed with HAEC using the previous scoring system.

“The new scoring system offers several advantages,” said Lewit. “The new score includes signs that are frequently seen in HAEC, maximizes sensitivity compared to previous scoring systems and is simple and designed specifically to be used in a clinical setting.”

Further study is needed to externally validate the new score before implementing clinically on a wide-scale.

 

About Le Bonheur Children’s:

Le Bonheur Children’s Hospital in Memphis, Tenn., treats children through community programs, regional clinics and a 255-bed state-of-the-art hospital. Le Bonheur serves as a primary teaching affiliate for the University Tennessee Health Science Center and trains more than 350 pediatricians and specialists each year. Nationally recognized, Le Bonheur is ranked by U.S. News & World Report as a Best Children’s Hospital. 

For more information, please call (901) 287-6030 or visit lebonheur.org. Connect with us at facebook.com/lebonheurchildrens, twitter.com/lebonheurchild or on Instagram at  lebonheurchildrens.

About University of Tennessee Health Science Center:

As Tennessee’s only public, statewide, academic health system, the mission of the University of Tennessee Health Science Center is to bring the benefits of the health sciences to the achievement and maintenance of human health through education, research, clinical care, and public service, with a focus on the citizens of Tennessee and the region. The main campus in Memphis includes six colleges: Dentistry, Graduate Health Sciences, Health Professions, Medicine, Nursing and Pharmacy. UTHSC also educates and trains medicine, pharmacy, and/or health professions students, as well as medical residents and fellows, at major sites in Knoxville, Chattanooga and Nashville. For more information, visit www.uthsc.edu. Find us on Facebook: facebook.com/uthsc, on Twitter: twitter.com/uthsc and on Instagram: instagram.com/uthsc


Posted: 8/6/21

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